Urolithin A 8-métil éter

April 8, 2021

Urolithins mangrupakeun metabolit sekunder asam ellagic diturunkeun tina ellagitannins. Dina manusa ellagitannins dirobih ku usus mikroflora kana asam ellagic anu salajengna dirobih janten urolithins A, urolithin B, urolithin C sareng urolithin D dina peujit ageung.

Urolithin video 8-Methyl Ether (35233-17-1)

 

Urolithin A 8-Methyl Ether (35233-17-1)spésifikasi

Ngaran Produk Urolithin bubuk 8-Methyl Éter
Ngaran kimia 3-hidroksi-8-methoxy-6H-benzo [c] chromen-6-hiji;

3-hidroksi-8-methoxybenzo [c] chromen-6-hiji;

35233-17-1;

MLS001049096;

SMR000386929;

ChemDiv3_002724;

Urolithin A 8-métil éter;

CAS Jumlah 35233-17-1
InChIKey IGJLBTGXYKPECW-UHFFFAOYSA-N
molekular Formula C14H10O4
molekular Wdalapan 242.23
Monoisotopic Massa 242.057909 g / mol
titik lebur 242 ° C (Solv: asét asétat (64-19-7))
titik golak  479.9 ± 38.0 ° C (Dugaang)
Déntitas 1.375 ± 0.06 g / cm3 (diprediksi)
Biologis Satengah-Kahirupan N / A
warna Beige Cahaya janten Pohara Jeruk Padet
Solubility  Acetone (Rada, Sonicated) DMSO (Rada, Sonicated), Métanol (Rada)
Storage Temperature  Hygroscopic, -20 ° C freezer, Dina atmosfir mulya
Application Urolithin A 8-Methyl Ether mangrupikeun panengah dina sintésis Urolithin A (U847000), hiji metabolit utama Ellagitannin sareng nunjukkeun sipat anti radang sareng antioksidan.

 

rujukan

[1] Espín, Juan Carlos; Larrosa, Mar; García-Conesa, María Teresa; Tomás-Barberán, Francisco (2013). "Signifikansi Biologis Urolithins, Metabolit Asam Asam Électric Gut Microbial: Bukti Sajauh ieu". Bukti Dumasar Bukti sareng Pangobatan Alternatif. 2013: 270418. doi: 1155/2013/270418. ISSN1741-427X. PMC 3679724. PMID 23781257.

[2] Ryu, Dongryeol; Mouchiroud, Laurent; Andreux, Pénélope A; Katsyuba, Elena; Moullan, Norman; Nicolet-dit-Félix, Amandine A; Williams, Evan G; Jha, Pooja; Sasso, Giuseppe Lo (2016). "Urolithin A nyababkeun mitophagy sareng manjangkeun umur di C. elegans sareng ningkatkeun fungsi otot dina rodénsia". Pangobatan Alam. 22 (8): 879–888. doi: 1038 / nm.4132. PMID 27400265.

[3] Ishimoto, Hidekazu; Shibata, Mari; Myojin, Yuki; Ito, Hideyuki; Sugimoto, Yukio; Tai, Akihiro; Hatano, Tsutomu (2011). "Dina vivo sipat anti-radang sareng antioksidan tina ellagitannin metabolit urolithin A" (PDF). Hurup Kimia Biologis & Obat. 21 (19): 5901-5904. doi: 1016 / j.bmcl.2011.07.086. PMID 21843938.

[4] Kasimsetty, SG, dkk .: J. Agri. Dahareun. Chem., 58, 2180 (2010);

[5] Bialonska, D., dkk .: J. Agri. Dahareun. Chem., 57, 10181 (2009);